Montana State University

Mark A. Young

Mark Young
Mark A. Young - Professor, PhD from University of California-Davis. 

Office: 111A Chemistry BioScience Building
Lab: 118 Chemistry BioScience Building

Office Phone: 406-994-5158
Lab Phone: 406-994-5137

Fax: 406-994-7600
 Email Dr. Young



RESEARCH

My program utilizes viruses to understand viral diseases and as model systems to explore cell biology. By combining biochemical and genetic approaches, with the tools of molecular and structural biology, I examine the interplay of viral and host gene products. Three principle areas of research are under investigation: (1) the study of spherical virus assembly and disassembly processes; (2) the use of viral protein cages as constrained reaction vessels for nano-materials synthesis; (3) and the isolation and genetic characterization of viruses from extreme thermal environments found in Yellowstone National Park.

AREA OF RESPONSIBILITY

Basic research in virology, teaching courses virology and biotechnology. Statewide diagnosis and characterization of viral diseases of importance to Montana agriculture. Director of Montana NSF EPSCoR program. Member of the MSU Thermal Biology Institute and Astrobiology Biogeocatalysis Research Center.

EDUCATION

  • B.S. Biochemistry, University of California, Berkeley, CA, 1980
  • B.S. Soils and Plant Nutrition, University of California, Berkeley, CA, 1980
  • Ph.D Plant Pathology (Plant Virology), University of California, Davis, CA, 1987

MEMBERSHIPS IN PROFESSIONAL ASSOCIATIONS

  • American Society for Virology
  • American Society for Microbiology
  • Molecular Biology and Biochemistry Society
  • American Association for the Advancement of Science

RECENT PROFESSIONAL ACTIVITES

  • National Executive Board, American Society for Virology (1999, 2000, 2001,2002)
  • NSF Microbiology Panel (2000, 2001,2002)
  • USDA‑NRI panel (1996, 1997,2002)
  • Scientific Advisory Board: Alaska NSF EPSCoR Program (2000, 2001,2002)

COMMITTEE MEMBERSHIPS

  • National Program Committee, American Society for Virology (1999, 2000, 2001, 2002)
  • National Nominations Committee, American Society for Virology (2001,2002)
  • NASA  Astrobiology Virus Committee (2002)

COURSES TAUGHT

  • BIO 415:        Intro. to Molecular Biology, Purdue
  • USP 490:       Undergrad Research, MSU Bozeman
  • PS 290:         Undergrad Research
  • PLP 518:       Vrology, MSU-Bozeman
  • PLP 519:       Virology Lab, MSU-Bozeman
  • PLP 541:       Molecular Methods, MSU Bozeman
  • PLP 521:       Plant Virology, MSU Bozeman
  • PLP 580:        Fundamental Virology, MSU Bozeman
  • PLP 690:        Doctoral Thesis, MSU Bozeman
  • CHEM 490:    Undergrad Research, MSU Bozeman
  • CHEM 590:    Doctoral Thesis, MSU Bozeman
  • CHEM690:     Doctoral Research, MSU Bozeman
  • MBEH 690:    Doctoral Research, MSU Bozeman


PUBLICATIONS FROM 1998 TO PRESENT

Refereed Articles

Wiley JA, Richert LE, Swain SD, Harmsen A, Barnard DL, Randall TD, Jutila M, Douglas T, Broomell C, Young M. Inducible Bronchus-Associated Lymphoid Tissue Elicited by a Protein Cage Nanoparticle Enhances Protection in Mice against Diverse Respiratory Viruses. Plos One 2009;4(9).

Varpness Z, Suci PA, Ensign D, Young MJ, Douglas T. Photosensitizer efficiency in genetically modified protein cage architectures. Chemical Communications 2009(25):3726-3728.

Uchida M, Willits DA, Muller K, Willis AF, Jackiw L, Jutila M, Young MJ, Porter AE, Douglas T. Intracellular Distribution of Macrophage Targeting Ferritin-Iron Oxide Nanocomposite. Advanced Materials 2009;21(4):458-+.

Szymczyna BR, Taurog RE, Young MJ, Snyder JC, Johnson JE, Williamson JR. Synergy of NMR, Computation, and X-Ray Crystallography for Structural Biology. Structure 2009;17(4):499-507.

Suci PA, Kang S, Young M, Douglas T. A streptavidin-protein cage Janus particle for polarized targeting and modular functionalization. Journal of the American Chemical Society 2009;131(26):9164-9165.

Maaty WS, Wiedenheft B, Tarlykov P, Schaff N, Heinemann J, Robison-Cox J, Valenzuela J, Dougherty A, Blum P, Lawrence CM and others. Something Old, Something New, Something Borrowed; How the Thermoacidophilic Archaeon Sulfolobus solfataricus Responds to Oxidative Stress. Plos One 2009;4(9).

Liepold LO, Abedin MJ, Buckhouse ED, Frank JA, Young MJ, Douglas T. Supramolecular Protein Cage Composite MR Contrast Agents with Extremely Efficient Relaxivity Properties. Nano Letters 2009;9(12):4520-4526.

Liepold L, Oltrogge LM, Suci PA, Young MJ, Douglas T. Correct Charge State

Assignment of Native Electrospray Spectra of Protein Complexes. Journal of the American Society for Mass Spectrometry 2009;20(3):435-442.

Li HY, Klem MT, Sebby KB, Singel DJ, Young M, Douglas T, Idzerda YU. Determination of anisotropy constants of protein encapsulated iron oxide nanoparticles by electron magnetic resonance. Journal of Magnetism and Magnetic Materials 2009;321(3):175- 180.

Lawrence CM, Menon S, Eilers BJ, Bothner B, Khayat R, Douglas T, Young MJ. Structural and Functional Studies of Archaeal Viruses. Journal of Biological Chemistry 2009;284(19):12599-12603.

Klem MT, Suci P, Britt DW, Young M, Douglas T. In-Plane Ordering of a Genetically Engineered Viral Protein Cage. Journal of Adhesion 2009;85(2-3):69-77.

Kang S, Suci PA, Broomell CC, Iwahori K, Kobayashi M, Yamashita I, Young M, Douglas T. Janus-like Protein Cages. Spatially Controlled Dual-Functional Surface Modifications of Protein Cages. Nano Letters 2009;9(6):2360-2366.

Kang S, Jolley CC, Liepold LO, Young M, Douglas T. From Metal Binding to Nanoparticle Formation: Monitoring Biomimetic Iron Oxide Synthesis within Protein Cages using Mass Spectrometry. Angewandte Chemie-International Edition 2009;48(26):4772-4776.

Brumfield SK, Ortmann AC, Ruigrok V, Suci P, Douglas T, Young MJ. Particle Assembly and Ultrastructural Features Associated with Replication of the Lytic Archaeal Virus Sulfolobus Turreted Icosahedral Virus. Journal of Virology 2009;83(12):5964-5970.

Banfield JF, Young M. Variety-the Splice of Life-in Microbial Communities. Science 2009;326(5957):1198-1199.

Abedin MJ, Liepold L, Suci P, Young M, Douglas T. Synthesis of a Cross-Linked Branched Polymer Network in the Interior of a Protein Cage. Journal of the American Chemical Society 2009;131(12):4346-4354.

Terashima M, Uchida M, Kosuge H, Young MJ, Douglas T, McConnell MV. Targeted Protein Cage Nanoparticles Detects Macrophages Accumulation in Mouse Atherosclerosis using Fluorescence Imaging. 2008. p S554-S555.

Schoenfeld T, Patterson M, Richardson PM, Wommack KE, Young M, Mead D. Assembly of viral metagenomes from Yellowstone hot springs. Applied and Environmental Microbiology 2008;74(13):4164-4174.

Ortmann AC, Brumfield SK, Walther J, McInnerney K, Brouns SJJ, van de Werken HJG, Bothner B, Douglas T, van de Oost J, Young MJ. Transcriptome analysis of infection of the Archaeon Sulfolobus solfataricus with Sulfolobus turreted icosahedral virus. Journal of Virology 2008;82(10):4874-4883.

Menon SK, Maaty WS, Corn GJ, Kwok SC, Eilers BJ, Kraft P, Gillitzer E, Young MJ, Bothner B, Lawrence CM. Cysteine usage in Sulfolobus spindle-shaped virus 1 and extension to hyperthermophilic viruses in general. Virology 2008;376(2):270-278.

Klem MT, Young M, Douglas T. Biomimetic synthesis of beta-TiO2 inside a viral capsid. Journal of Materials Chemistry 2008;18(32):3821-3823.

Klem MT, Mosolf J, Young M, Douglas T. Photochemical mineralization of europium, titanium, and iron oxyhydroxide nanoparticies in the ferritin protein cage. Inorganic Chemistry 2008;47(7):2237-2239.

Kang S, Oltrogge LM, Broomell CC, Liepold LO, Prevelige PE, Young M, Douglas T. Controlled Assembly of Bifunctional Chimeric Protein Cages and Composition Analysis Using Noncovalent Mass Spectrometry. Journal of the American Chemical Society 2008;130(49):16527-+.

Suci PA, Varpness Z, Gillitzer E, Douglas T, Young M. Targeting and photodynamic killing of a microbial pathogen using protein cage Architectures functionalized with a photosensitizer. Langmuir 2007;23(24):12280-12286.

Snyder JC, Wiedenheft B, Lavin M, Roberto FF, Spuhler J, Ortmann AC, Douglas T, Young M. Virus movement maintains local virus population diversity. Proceedings of the National Academy of Sciences of the United States of America 2007;104(48):19102- 19107.

Kaiser CR, Flenniken ML, Gillitzer E, Harmsen AL, Harmsen AG, Jutila MA, Douglas T, Young MJ. Biodistribution studies of protein cage nanoparticles demonstrate broad tissue distribution and rapid clearance in vivo. International Journal of Nanomedicine 2007;2(4):715-733.

Klem, M. T., Resnick, D. A., Gilmore, K., Young, M., Idzerda, Y. U., and Douglas, T. (2007). Synthetic control over magnetic moment and exchange bias in all-oxide materials encapsulated within a spherical protein cage. J Am Chem Soc 129(1), 197- 201.

Uchida, M., Flenniken, M. L., Allen, M., Willits, D. A., Crowley, B. E., Brumfield, S., Willis, A. F., Jackiw, L., Jutila, M., Young, M. J., and Douglas, T. (2006). Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles. J Am Chem Soc 128(51), 16626-33.

Suci, P. A., Klem, M. T., Arce, F. T., Douglas, T., and Young, M. (2006). Assembly of multilayer films incorporating a viral protein cage architecture. Langmuir 22(21), 8891-6.

Speir, J. A., Bothner, B., Qu, C., Willits, D. A., Young, M. J., and Johnson, J. E. (2006). Enhanced local symmetry interactions globally stabilize a mutant virus capsid that maintains infectivity and capsid dynamics. J Virol 80(7), 3582-91.

Tang, J., Johnson, J. M., Dryden, K. A., Young, M. J., Zlotnick, A., and Johnson, J. E. (2006). The role of subunit hinges and molecular "switches" in the control of viral capsid polymorphism. J Struct Biol 154(1), 59-67.

Flenniken, M.L., Willits, D.A., Harmsen, A.L., Liepold, L.O., Harmsen, A.G., Young, M. J., Douglas., T. 2006. Melanoma and lymphocyte cell-specific targeting incorporated into a heat shock protein cage architecture. Chemistry and Biology. 13(2):161-70.

Ramsay, B., Wiedenheft, B., Allen, M., Gauss, G. H., Lawrence, C. M., Young, M., and Douglas, T. (2006). Dps-like protein from the hyperthermophilic archaeon Pyrococcus furiosus. J Inorg Biochem 100(5-6), 1061-8.

Khayat, R., Tang, L., Larson, E.T., Lawrence, C.M., Young, M., Johnson, J.E. Structure of an archaeal virus capsid protein reveals a common ancestry to eukaryotic and bacterial viruses. Proc. Natl. Acad. Sci. USA, 102:18944-18949, 2005.

Wiedenheft, B., Mosolf, J., Willits, D., Yeager, M., Dryden, K.A., Young, M., Douglas, T. An archaeal antioxidant: Characterization of a Dps-like protein from Sulfolobus solfataricus. Proc. Natl. Acad. Sci. USA, 102:10551-10556, 2005.

Botero, L.M., D'Imperio, S., Burr, M., McDermott, T.R., Young, M., Hassett, D.J. Poly(A) polymerase modification and reverse transcriptase PCR amplification of environmental RNA. Appl Environ Microbio 71: 1267-1275, 2005.

Varpness, Z., Peters, J., Young, M., Douglas, T. Biomimetic synthesis of a H2 catalyst using a protein cage Architecture. Nano Letters, 5:2306-2309, 2005.

Willits, D., Zhao, X., Olson, N., Baker, T.S., Zlotnick, A., Johnson, J.E., Douglas, T., Young, M. J. Effects of the Cowpea chlorotic mottle bromovirus -hexamer structure on virion assembly. Virology, 306:280-288, 2003.

Flenniken, M., Willits, D., Brumfield, S., Young, M., Douglas, T. The small heat shock protein from Methanococcus jannaschii is a versatile nano-scale platform for genetic and chemical modifications. Nano Letters, 3:1573-1556, 2003.

Klem, M., Willits, D., Young, M., Douglas, T. 2-D Array formation of genetically engineered viral cages on Au surfaces and imaging by atomic force microscopy. JACS, 125:1056-1057, 2003.

Willits, D., Zhao, X., Brumfield, S., Zlotnick, A., Johnson, J.E., Baker, T. and M. Young.  Mutational analysis of the Cowpea chlorotic mottle bromovirus b-hexamer structure on virion assembly and stability.  Virology (in review).

Gillitzer, E., Willits, D., Douglas, T. and M Young. Chemical modifation of a viral cage for multivalent presentation. Chem. Comm. 2002 (in press).

Douglas, T., Allen, M., and M. Young. Self-assembling protein cage systems and applications in nanotechnology. Biopolymer. 2002 (in press).

Douglas, T., Strable, E., Willits, D., Aitouchen, A., Libera, M., and M. Young. Protein engineering of a viral cage for constrained nano-materials synthesis. Adv. Mater 14:123-133. 2002.88

Rice, G., Stedman, K., Snyder, J., Wiedenheft, B., Willits, D., Brumfield, S., McDermott, T., and M. Young.  Viruses from extreme thermal environments. Proc. Natl. Acad. Sci. USA 98: 13341-13345. 2001.

Schneemann, A., and M. Young. Viral assembly using heterologous expression systems and cell extracts.  Adv. Protein Chem. 2001.

Botero, L., Burr, M., Willits, D., Elkins, J., Inskeep, W., Young, M., and T. McDermott.  Prokaryote diversity in an extreme thermal soil. Appl. Environ Microbiol. 2001.

Botero, L., Fredericks, J., Burr, M., Wraith, J., Inskeep, W., Young, M., and T. Mc Dermott.  Surface-associated culturing approach provides for significantly improved cultivation of thermophilic soil microbes. Journal. 2001.

Baley, G., Talbert, L., Martin, J., Young, M., Habernicht, D., Kushnak, G., Berg, J., Lanning, S., and P. Bruckner.  Agronomic and end-use qualities of Wheat streak mosaic virus resistant spring wheat. Crop Sci.41:1779-1784. 2001.

Elumalai, S., Brey, C., Dyer, W., Talbert, L., Young, M., Qu,R. Resistance to wheat streak mosaic virus mediated by an RNA replicase gene in transgenic wheat. Transgenic Research 2001.

Zlotnick, A., Aldrich, R. Johnson, J., Ceres, P., and M. Young. Mechanism of capsid assembly for an icosahedral plant virus.  Virology 277, 450-456 (2000).

Douglas, T., Young, M. J., Virus particles as templates for nanophase materials synthesis, Adv. Mater., 11: 679-681, 1999.

Shenton, W., Douglas, T., Young, M., Stubbs, G., Mann, S.,  Inorganic-organic nanotube composites from template mineralization of tobacco mosaic virus, Adv. Mater., 11: 253-256, 1999.

Douglas, T., Young, M. J., Virus particles as templates for nanophase materials synthesis, Adv. Mater., 11: 679-681, 1999.

Young, M., Flichkin, S., Luteovirus interactions with aphid vector cellular components.  Trends MicroBio. 7:466-348, 1999.

Douglas, T., Young, M. J., Host -guest encapsulation of materials by assembled virus protein cages, Nature  393:152-155, 1998.

Fox, J., Wang, G., Speir, J., Olson, N., Johnson, J., Baker, T., Young, M., Comparison of the native CCMV virion with in vitro assembled CCMV virions by cryo-electron microscopy and image reconstruction.  Virology, 224:212-218, 1998.

Abstracts

Rice, G., Stedman, K, J. Snyder and M Young. Three novel viruses from high temperature acidic environments.  Viral Assembly Meeting, FASEB Summer Research Conferences.  Saxtons River VT, June 22-26, 2002.

Young, M., Rice, G., Stedman, K., Snyder, J., Wiedenheft, B., Willits, D., Brumfield, S., McDermott, T., and M. Young.  Viruses from extreme thermal environments. Astobiology 2002, Mountain View  Ca May 5-8, 2002.

Rice, G., Stedman, K., Snyder, J., and M. Young.  The discovery of new viruses from extreme thermal environments of Yellowstone National Park.  Gordon Research Conference: Archaea 

Ecology, Metabolism and Molecular Biology. Proctor Academy, Andover New Hampshire, August 5-10, 2001 (Abst. 26).

Snyder, J., Rice, G., Stedman, K., Prangishvili, D. and M. Young.  Exploring the diversity of Sulfolobus viruses from extreme thermal environments of Yellowstone National Park.  Gordon Research Conference: Archaea Ecology, Metabolism and Molecular Biology. Proctor Academy, Andover New Hampshire, August 5-10, 2001 (Abs. 31).

Douglas, T, Young,  M., Libera, M., Strable, E., Willits, D., and A. Aitouchen.  Biomimetic mineralization in engineered viral protein cages.

Crowley, C, Willits, D., Douglas, T., and M. Young. Protein engineering a reversible chemical switch for controlling structural transitions in a spherical virus. 20th Annual Meeting, American Society for Virology, University of Wisconsin-Madison, July 21-25,2001 (Abst. W50-3).

Willits, D., Brumfield, S., Strable, E., Zhao, X., Douglas, T., and M. Young. Analysis of metal binding in the assembly of Cowpea chlorotic mottle virus. 20th Annual Meeting, American Society for Virology, University of Wisconsin-Madison, July 21-25,2001 (Abst. W50-4).

Brumfield, S., Willits, d., Tang, L., Johnson, J.E., and M. Young. A Pichia pastoris expression system used to express empty Cowpea chlorotic mottle virus particles.  20th Annual Meeting, American Society for Virology, University of Wisconsin-Madison, July 21-25,2001 (Abst. W50-5).

Wiedenheft, B., Brouns, S., Garrett, R.A., Schleper, C., She, Q., Stedman, K., Martusewitch, E., and M. Young. A viral based transformation system for hyperthermophiles. 20th Annual Meeting, American Society for Virology, University of Wisconsin-Madison, July 21-25,2001 (Abst. W52-10).

Snyder, J., Rice, G., Stedman, K., Wiedenheft, B., and M. Young. Exploring the diversity of Sulfolobus viruses from extreme thermal environments of Yellowstone National Park. 20th Annual Meeting, American Society for Virology, University of Wisconsin-Madison, July 21-25,2001 (Abst. W53-10).

Rice, G., Stedman, K., Snyder, J., and M. Young. Discovery of three new viruses from extreme thermal environments of Yellowstone National Park. 20th Annual Meeting, American Society for Virology, University of Wisconsin-Madison, July 21-25,2001 (Abst. W53-11).

Wiedenheft, B. and M. Young. The diversity of Saves in Yellowstone National Park and around the world.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  March 24-25, 2001.

Stedman, K., and M. Young. Russian Roulette. MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  March 24-25, 2001.

Brouns, S., and M. Young. Developing a Sulfolobus solfataricus based expression system. MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  March 24-25, 2001.

Rice, G., and M Young. Discovery of two new viruses from extreme thermal environments of Yellowstone National Park. MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  March 24-25, 2001.

Snyder, J., and M Young. Cloning and sequencing of SIRV and SIFV from Yellowstone National Park. MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  March 24-25, 2001.

Brumfield, S., and M. Young. Heterologous expression systems to assemble modified CCMV-based protein cages. MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  March 24-25, 2001.

Crowley, C. and M. Young. Protein engineering a chemical switch into a viral cage. MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  March 24-25, 2001.

Li, N., and M. Young. Characterization of a mutant of CCMV and its indication for virus disassembly.  19th Annual Meting, Colorado State University, Fort Collins Co July 8-12, 2000 (Abst W2-2)

Arnold, T., Starkey, J., Willits, D., and M. Young. Heterologous expression of laminin peptide 11 on a virus particle surface for use in malignant cell targeting.  19th Annual Meting, Colorado State University, Fort Collins Co July 8-12, 2000 (Abst W28-10).

Willits, D., Zhao, X., Strable, E., Douglas, T., and M. Young. The putative role of calcium in CCMV virus assembly.  19th Annual Meting, Colorado State University, Fort Collins Co July 8-12, 2000 (Abst W30-6).

Rice, G. Snyder, J., Redfield, E., and M. Young. The discovery of thermophilic viruses in Yellowstone National Park.  19th Annual Meting, Colorado State University, Fort Collins Co July 8-12, 2000 (Abst W47-1).

Snyder, J. Rice, G., Redfield, E. and M. Young. Investigating the diversity of Sulfolobus species and their viruses in Yellowstone National Park.  19th Annual Meting, Colorado State University, Fort Collins Co July 8-12, 2000 (Abst W47-2)

Sonic, A., Johnson, J., Ceres, P., Endres, D., Wingfield, P., and M Young. Different assembly mechanisms are observed for different icosahedral capsids.  Viral Assembly Meeting, FASEB Summer Research Conferences.  Saxtons River VT, June 10-15, 2000.

Young, M., Rice, G., Snyder, J., Redfield, E., and K. Stedman.  Novel Viruses from Extreme Thermal Environments of Yellowstone National Park. Viral Assembly Meeting, FASEB Summer Research Conferences.  Saxtons River VT, June 10-15, 2000.

Starkey, J., Young, M., and T.  Arnold. Development of a viral protein cage system for targeting malignant solid tumor cells.  Cancer 2000. Washington, D.C.  July 7-13. 2000.

Mansilla, C., Sanchez, F., Aguilar, I., Ponz, F., Brumfield, S., Young, M., Padgett, H. and G. Pogue.  Determinantes de pathogenicidad en tobamovirus.  VI Congress in Virologia.  Majadahonda, Spain Oct. 24-27, 2000.

Willits, D., and M Young. Structure based modifications of CCMV and their biological implications.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000.

Strable, E., Willits, D., Young, M., and T. Douglas.  Analysis of the CCMV calcium binding region.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000.

Young, M., and T. Douglas, T. CCMV as a model for viral protein cages as constrained reaction vessels.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000. 

Douglas, T., and M. Young. Modification of viral protein cages for material synthesis and entrapment.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000.

Pincus, Z., and M Young. Systematic analysis of CCMV surface loops to express heterologous protein sequences.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000.

Arnold, T., and M. Young. Targeting CCMV protein cages to cancer cells: Implications for bio imaging and therapy.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000.

Rice, G., and M Young. Viruses from extreme environments.  MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000.

Snyder, J., Diversity of SSV-like viruses and their hosts from Yellowstone National Park. MontDiego Meeting, Scripps Research Institute, La Jolla, CA.  Feb. 11-12, 2000.

Young, M. Viruses from Extreme Thermal Environments.  Proceedings of NASA Workshop on Life in Extreme Environments. Big Sky, MT. March 6-7, 2000.

Botero, Lina M., Jesse Fredericks, Jon Wraith, Mark Young, and Timothy R. McDermott. Biofilm drip flow chemostat provides for significantly improved cultivation of environmental isolates. NASA Life in Extreme Environments Workshop. Big Sky, MT March, 2000.

Burr, M., M. Young, and T.R. McDermott. Characterization of the nitrogen cycle in an extreme thermal soil. NASA Life in Extreme Environments Workshop. Big Sky, MT March, 2000.

McDermott, T.R., Mark Young, W.P. Inskeep, and Jon Wraith. Prokaryote Diversity in an Extreme Thermal Soil. First Astrobiology Conference, Ames, CA April 3-5, 2000.

H.P. Arnold, E. Bonch-Osmolovskaya, R. Garrett, H. Phan, J.K. Kristjansson, E. Redfield, G. Rice, F. Robb, Q. She, J. Snyder, K. M. Stedman, B. Wiedenheft, M. Young, and W. Zillig. Biodiversity in Fuselloviruses from Japan, Iceland, Yellowstone USA, and Kamchatka, Russia.  West Coast Bacterial Physiologists Annual Asilomar Meeting.  December 15-18, 2000. Diversity and Similarity of SSV viruses from Yellowstone, Iceland and Japan:  SSVs are everywhere.

K. Stedman, H.P. Arnold, D. Prangishvili, E. Redfield, G. Rice, J. Snyder, H. Phan, Q. She, R. A. Garrett, M. Young and W. Zillig. Symposium on the Origin and Evolution of Viruses, Les Treilles, France.  July 24-30, 2000.

Willits, D., Zhao, X., Baker, T., Young, M. Analysis of CCMV structural features. XI International Congress of Virology.  August 9-13, 1999.  Sydney Australia (VW49.07).

Berger, P., McCarthey, P., Hansen, J., Shiel, P., Wyatt, S., Bosque-Perez, N., Zemetra, R., Young, M.  Coat protein-mediated resistance to barley yellow dwarf and wheat streak mosaic in soft white winter wheat. XI International Congress of Virology.  August 9-13, 1999.  Sydney Australia (VP57.22).

Young, M., Douglas, T.  CCMV as a constrained reaction vessel for inorganic and organic material synthesis. XI International Congress of Virology.  August 9-13, 1999.  Sydney Australia (V41RS.2).

Starkey, J., Young, M., Arnold, T.  Development of a viral protein cage system for targeting malignant solid tumor cells.  Molecular Targets and Cancer Therapeutics: Discovery, Development, and Clinical Validation.  NCI November 16-19, 1999, Washington DC.

Young, M. Development and Scientific Program of the Thermal Biology Institute.  Montana EPSCoR Meeting.  November 1-3, 1999. Missoula MT.

Filichkin, S., Brumfield, S., and Young, M. 1998.  Cowpea chlorotic mottle virus:  Evidence of covalent bond formation between N-terminal portions of two coat protein subunits. 17th Annual Meeting American Society of Virology. July 11-15,  Vancouver, British Columbia, Canada 9Abst. P12-2).

Li, N., Brumfield, S., and Young, M. 1998.  Analysis of CCMV Co-translational disassembly. 17th Annual Meeting American Society of Virology. July 11-15,  Vancouver, British Columbia, Canada (Abst W28-3).

Filichkin, S., Brumfield, S., Filichkin, T., and Young, M. 1998. Identification of capsid protein domains involved in transmission specificity of barley yellow dwarf virus. 17th Annual Meeting American Society of Virology. July 11-15,  Vancouver, British Columbia, Canada  (Abst. P6-25).

Books and book chapters

Young, M. and D. Willits. Virus Structure In Encyclopedia of Plant Pathology, (O. Maloy and T. Murry Eds) John Wiley & Sons. (2000).

Young, M. J., Filichkin, S., and Van der Houvel.  1998.  The role of SymL in Barley Yellow Dwarf Virus biology. In Host - Virus Interactions. Plenum Press, New York.

Patents

Young, M.J. and T. Douglas. 2000. Nanoscale inorganic and organic materials synthesized within virus particles. (issued).

Young, M.  Virion-constrained nanoparticles comprising a plant virion coat protein shell and encapsulated guest molecules.  2000.  Patents issued in Japan, Australia, United Kingdom, France, Germany, Spain, Italy.

Young, M., D. Atkins, J. Fillatti, L. Kelly, and W. L. Gerlach. 1993. Nucleic acids and methods of  use thereof for controlling viral pathogens. (42710‑PCT).

Young, M.J., J. Fillatti, and W.L. Gerlach. 1991. Gene expression Patent (# 4295‑PAS).


CURRENT PROGRAMS

Administrative

  1. Director, NSF EPSCoR Program
  2. Co-Director MSU Thermal Biology Institute

Research

  1. The use of viral protein cages as templates for nano materials synthesis
  2. The discovery and characterization of viruses from extreme environments

Teaching

  1. Graduate level virology
  2. Undergraduate biotechnology laboratory
  3. Undergraduate Virology